New substituted imidazole compounds, useful e.g. to treat cancer, pathological consequences of alcohol abuse, viral hepatitis, acute and chronic pancreatitis, toxic renal disease and hepatic insulin resistance in diabetes mellitus

Substituted imidazole compounds (I) and their salts, are new. Substituted imidazole compounds of formula (I) and their salts, are new. R1 : H, halo, 1-6C-alkyl, 3-8C-cycloalkyl or aryl; R2 : H, halo, 1-6C-alkyl or 3-8C-cycloalkyl; R3 : H, halo, 1-6C-alkyl, 1-6C-alkyl-carbamoyl, aryl-carbamoyl or ary...

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Hauptverfasser: DIESINGER, TORSTEN, HAEHNER, THOMAS
Format: Patent
Sprache:eng ; ger
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Zusammenfassung:Substituted imidazole compounds (I) and their salts, are new. Substituted imidazole compounds of formula (I) and their salts, are new. R1 : H, halo, 1-6C-alkyl, 3-8C-cycloalkyl or aryl; R2 : H, halo, 1-6C-alkyl or 3-8C-cycloalkyl; R3 : H, halo, 1-6C-alkyl, 1-6C-alkyl-carbamoyl, aryl-carbamoyl or aryl-1-2C-alkyl-carbamoyl; n : 7-14; and m, p : 0-2. [Image] ACTIVITY : Cytostatic; Antialcoholic; Antiaddictive; Antiinflammatory; Hepatotropic; Virucide; Nephrotropic; Antidiabetic; Vasotropic; Antilipemic. MECHANISM OF ACTION : None given. Imidazole der Formel (1)worin n 7-14 und m 0, 1 oder 2 bedeutet, p 0, 1 oder 2 bedeutet, R1 H, Halogen, C1-C6-Alkyl, C3-C8-Cycloalkyl oder Aryl bedeutet, R2 H, Halogen, C1-C6-Alkyl oder C3-C8-Cycloalkyl bedeutet, und R3 H, Halogen, C1-C6-Alkyl, C1-C6-Alkyl-carbamoyl, Aryl-carbamoyl oder Aryl-C1-C2-alkyl-carbamoyl bedeutet, pharmazeutisch akzeptable Salze davon und entsprechende pharmazeutische Präparate.