Pharmaceutical preparation, useful for the intravenous treatment of paracetamol intoxication, comprises 12-imidazolyl-1-dodecanol or its salt

Pharmaceutical preparation comprises 12-imidazolyl-1-dodecanol or its salt. An independent claim is also included for producing the pharmaceutical preparation comprising mixing the components. ACTIVITY : Antidote. MECHANISM OF ACTION : Cytochrome P450 2E1 enzyme inhibitor. The ability of 12-imidazol...

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Bibliographische Detailangaben
Hauptverfasser:	DIESINGER, TORSTEN, HAEHNER, THOMAS
Format:	Patent
Sprache:	eng ; ger
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	Pharmaceutical preparation comprises 12-imidazolyl-1-dodecanol or its salt. An independent claim is also included for producing the pharmaceutical preparation comprising mixing the components. ACTIVITY : Antidote. MECHANISM OF ACTION : Cytochrome P450 2E1 enzyme inhibitor. The ability of 12-imidazolyl-1-dodecanol to inhibit cytochrome P450 2E1 enzyme was tested in microsome extracts from the rat liver using para-nitrophenol hydroxylation assay. The results showed that the imidazolyl-dodecanol in cyclodextrin exhibited IC 50value of 402.73 nM. Pharmazeutisches Präparat enthaltend 12-Imidazolyl-1-dodecanol oder ein pharmazeutisch akzeptables Salz davon zur intravenösen Behandlung einer Paracetamol-Intoxikation.