New crystalline hydrate form of dodecanedioic acid 4-((2S,3R)-3-((S)-3-(4-fluoro-phenyl)-3-hydroxy-propyl)-2-(4-methoxy-phenyl)-4-oxo-azetidin-1-yl)-benzylamide ((2S,3R,4R,5R)-pentahydroxy-hexyl)-amide useful e.g. to treat hyperlipidemia

New crystalline hydrate form of dodecanedioic acid 4-((2S,3R)-3-((S)-3-(4-fluoro-phenyl)-3-hydroxy-propyl)-2-(4-methoxy-phenyl)-4-oxo-azetidin-1-yl)-benzylamide ((2S,3R,4R,5R)-pentahydroxy-hexyl)-amide useful e.g. to treat hyperlipidemia

Crystalline dodecanedioic acid 4-[(2S,3R)-3-[(S)-3-(4-fluoro-phenyl)-3-hydroxy-propyl]-2-(4-methoxy-phenyl)-4-oxo-azetidin-1-yl]-benzylamide ((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxy-hexyl)-amide (A) in hydrate form (I), is new. Crystalline dodecanedioic acid 4-[(2S,3R)-3-[(S)-3-(4-fluoro-phenyl)-3-hydr...

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Bibliographische Detailangaben
Hauptverfasser: WOLLMANN, THEODOR ANDREAS, CULLMANN, FRANK, DUFFY, REGINA
Format: Patent
Sprache:eng ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Crystalline dodecanedioic acid 4-[(2S,3R)-3-[(S)-3-(4-fluoro-phenyl)-3-hydroxy-propyl]-2-(4-methoxy-phenyl)-4-oxo-azetidin-1-yl]-benzylamide ((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxy-hexyl)-amide (A) in hydrate form (I), is new. Crystalline dodecanedioic acid 4-[(2S,3R)-3-[(S)-3-(4-fluoro-phenyl)-3-hydroxy-propyl]-2-(4-methoxy-phenyl)-4-oxo-azetidin-1-yl]-benzylamide ((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxy-hexyl)-amide (A) in hydrate form of formula (I), is new. n : 0.5-1.8, preferably 1-1.2. Independent claims are included for: (1) a medicament comprising (I); and (2) the preparation of (I). [Image] ACTIVITY : Antilipemic. MECHANISM OF ACTION : None given. Die Erfindung betrifft kristalline Hydrate der Formel I $F1 worin n einen Wert von 0,5 bis 1,8 besitzt. Die Verbindung eignet sich z.B. als Hypolipidämikum.