Diagnostic kit, useful for assessing a subject's tolerance of drugs, comprises reagents for determining alleles of genes encoding detoxification enzymes
Diagnostic kit (A) for determining tolerance of pharmaceuticals in humans. Diagnostic kit (A) for determining tolerance of pharmaceuticals in humans comprises two pairs of oligonucleotide (ON) primers, in which each pair amplifies, by PCR, one of two complementary strands of a selected DNA segment (...
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| description | Diagnostic kit (A) for determining tolerance of pharmaceuticals in humans. Diagnostic kit (A) for determining tolerance of pharmaceuticals in humans comprises two pairs of oligonucleotide (ON) primers, in which each pair amplifies, by PCR, one of two complementary strands of a selected DNA segment (I). (I) is part of a gene (II) for a human enzyme involved in phase I and/or II of the detoxification mechanism, and the two primer pairs amplify different (I). Independent claims are also included for the following: (1) method for determining tolerance to pharmaceuticals by determining allelic variability of at least two polymorphisms of (II) in a blood, tissue or other human sample, where tolerance is determined from presence or absence of alleles; (2) microarray, e.g. DNA chip, carrying oligonucleotide probes able to hybridize to (I); and (3) diagnostic kit containing the microarray of (2).
Die Erfindung betrifft einen Mikroarray, beispielsweise DNS-Chip, mit einer Anordnung von mehreren, voneinander getrennten Zellen (Feldern), wobei in mindestens einer Zelle des Mikroarrays ein Oligonukleotid angeordnet ist, das mit einem DNS-Abschnitt hybridisiert, der Teil des menschlichen Gens für die N-Acetyltransferase 2, für die Tiopurin-S-Methyltransferase oder für das Cytochrom P4503A4 ist. |
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Die Erfindung betrifft einen Mikroarray, beispielsweise DNS-Chip, mit einer Anordnung von mehreren, voneinander getrennten Zellen (Feldern), wobei in mindestens einer Zelle des Mikroarrays ein Oligonukleotid angeordnet ist, das mit einem DNS-Abschnitt hybridisiert, der Teil des menschlichen Gens für die N-Acetyltransferase 2, für die Tiopurin-S-Methyltransferase oder für das Cytochrom P4503A4 ist.</description><edition>7</edition><language>eng ; ger</language><subject>BEER ; BIOCHEMISTRY ; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY ; CHEMISTRY ; COMBINATORIAL CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; ENZYMOLOGY ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES ; MEASURING ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; PERFORMING OPERATIONS ; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL ; PHYSICS ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; SPIRITS ; TESTING ; THEIR RELEVANT APPARATUS ; TRANSPORTING ; VINEGAR ; WINE</subject><creationdate>2003</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20030403&DB=EPODOC&CC=DE&NR=10140651A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20030403&DB=EPODOC&CC=DE&NR=10140651A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>WASCHUETZA, STEFANIE</creatorcontrib><creatorcontrib>LUSTIG, MICHAEL</creatorcontrib><creatorcontrib>SCHNAKENBERG, ECKART</creatorcontrib><title>Diagnostic kit, useful for assessing a subject's tolerance of drugs, comprises reagents for determining alleles of genes encoding detoxification enzymes</title><description>Diagnostic kit (A) for determining tolerance of pharmaceuticals in humans. Diagnostic kit (A) for determining tolerance of pharmaceuticals in humans comprises two pairs of oligonucleotide (ON) primers, in which each pair amplifies, by PCR, one of two complementary strands of a selected DNA segment (I). (I) is part of a gene (II) for a human enzyme involved in phase I and/or II of the detoxification mechanism, and the two primer pairs amplify different (I). Independent claims are also included for the following: (1) method for determining tolerance to pharmaceuticals by determining allelic variability of at least two polymorphisms of (II) in a blood, tissue or other human sample, where tolerance is determined from presence or absence of alleles; (2) microarray, e.g. DNA chip, carrying oligonucleotide probes able to hybridize to (I); and (3) diagnostic kit containing the microarray of (2).
Die Erfindung betrifft einen Mikroarray, beispielsweise DNS-Chip, mit einer Anordnung von mehreren, voneinander getrennten Zellen (Feldern), wobei in mindestens einer Zelle des Mikroarrays ein Oligonukleotid angeordnet ist, das mit einem DNS-Abschnitt hybridisiert, der Teil des menschlichen Gens für die N-Acetyltransferase 2, für die Tiopurin-S-Methyltransferase oder für das Cytochrom P4503A4 ist.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMBINATORIAL CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>ENZYMOLOGY</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES</subject><subject>MEASURING</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PERFORMING OPERATIONS</subject><subject>PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL</subject><subject>PHYSICS</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>THEIR RELEVANT APPARATUS</subject><subject>TRANSPORTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2003</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjD0OwjAMhbswIOAOZmIpUit-dkSLOAB7FVInMqRxFacScBKOS6g4AJOf_L73TbN3Rcp6lkga7hRzGATN4MBwACWCIuQtKJDhekMdVwKRHQblNQIbaMNgJQfNXR8o0RBQWfRRRkGLEUNHflQ4hy4BaZSAFNBrbr9NovhBhrSKxD79X88OZZ5NjHKCi9-dZctTfTme19hzg9IrnSyxqeqyKLfFflceys0_zAd5DlKn</recordid><startdate>20030403</startdate><enddate>20030403</enddate><creator>WASCHUETZA, STEFANIE</creator><creator>LUSTIG, MICHAEL</creator><creator>SCHNAKENBERG, ECKART</creator><scope>EVB</scope></search><sort><creationdate>20030403</creationdate><title>Diagnostic kit, useful for assessing a subject's tolerance of drugs, comprises reagents for determining alleles of genes encoding detoxification enzymes</title><author>WASCHUETZA, STEFANIE ; LUSTIG, MICHAEL ; SCHNAKENBERG, ECKART</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_DE10140651A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; ger</language><creationdate>2003</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMBINATORIAL CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>ENZYMOLOGY</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES</topic><topic>MEASURING</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PERFORMING OPERATIONS</topic><topic>PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL</topic><topic>PHYSICS</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>THEIR RELEVANT APPARATUS</topic><topic>TRANSPORTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>WASCHUETZA, STEFANIE</creatorcontrib><creatorcontrib>LUSTIG, MICHAEL</creatorcontrib><creatorcontrib>SCHNAKENBERG, ECKART</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>WASCHUETZA, STEFANIE</au><au>LUSTIG, MICHAEL</au><au>SCHNAKENBERG, ECKART</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Diagnostic kit, useful for assessing a subject's tolerance of drugs, comprises reagents for determining alleles of genes encoding detoxification enzymes</title><date>2003-04-03</date><risdate>2003</risdate><abstract>Diagnostic kit (A) for determining tolerance of pharmaceuticals in humans. Diagnostic kit (A) for determining tolerance of pharmaceuticals in humans comprises two pairs of oligonucleotide (ON) primers, in which each pair amplifies, by PCR, one of two complementary strands of a selected DNA segment (I). (I) is part of a gene (II) for a human enzyme involved in phase I and/or II of the detoxification mechanism, and the two primer pairs amplify different (I). Independent claims are also included for the following: (1) method for determining tolerance to pharmaceuticals by determining allelic variability of at least two polymorphisms of (II) in a blood, tissue or other human sample, where tolerance is determined from presence or absence of alleles; (2) microarray, e.g. DNA chip, carrying oligonucleotide probes able to hybridize to (I); and (3) diagnostic kit containing the microarray of (2).
Die Erfindung betrifft einen Mikroarray, beispielsweise DNS-Chip, mit einer Anordnung von mehreren, voneinander getrennten Zellen (Feldern), wobei in mindestens einer Zelle des Mikroarrays ein Oligonukleotid angeordnet ist, das mit einem DNS-Abschnitt hybridisiert, der Teil des menschlichen Gens für die N-Acetyltransferase 2, für die Tiopurin-S-Methyltransferase oder für das Cytochrom P4503A4 ist.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY COMBINATORIAL CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING THEIR RELEVANT APPARATUS TRANSPORTING VINEGAR WINE |
| title | Diagnostic kit, useful for assessing a subject's tolerance of drugs, comprises reagents for determining alleles of genes encoding detoxification enzymes |
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