New 4-phenyl- and 4-(4-substituted-phenyl)-n-butane-1-hydroxy-1,1-diphosphonic acids and per(trimethylsilyl) esters and known analogs are useful as targeted cytostatic drugs

The invention relates to a method of producing the 1-hydroxy-1,1-diphosphonic acid compounds of general formula (I), and/or the pharmacologically acceptable salts thereof, in which formula R represents hydrogen, OH, NO2, Cl, F, Br, C1-C6 alkyl that may be substituted with halogen, amine and/or amino...

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Bibliographische Detailangaben
Hauptverfasser:	GREB, WOLFGANG, PUSTOVIT, YURII, BLUM, HELMUT, ROESCHENTHALER, GERD-VOLKER
Format:	Patent
Sprache:	eng ; ger
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM AMUSEMENTS CHEMISTRY CONJURING APPLIANCES OR THE LIKE DEVICES FOR THEATRES, CIRCUSES, OR THE LIKE FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J GAMES HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL SPORTS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
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