N-substituierte p-Aminoethylsulfonanilide als antiarrhythmische Mittel und Zwischenprodukte daf}r

Compounds of the formula:- and their salts, wherein R is -NO2, -NH2 or -NHSO2R where R is a C1-C4 alkyl group; R is-NO2, -NH2 or R where R is-NHSO2(C1-C4 alkyl) or -CONR R where R and R are each independently H or C1-C4 alkyl or together with the nitrogen atom to which they are attached represent a...

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Hauptverfasser: THOMAS GEOFFREY NOEL, CROSS PETER EDWARD
Format: Patent
Sprache:ger
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Zusammenfassung:Compounds of the formula:- and their salts, wherein R is -NO2, -NH2 or -NHSO2R where R is a C1-C4 alkyl group; R is-NO2, -NH2 or R where R is-NHSO2(C1-C4 alkyl) or -CONR R where R and R are each independently H or C1-C4 alkyl or together with the nitrogen atom to which they are attached represent a 1-pyrrolidinyl, piperidino, morpholino or N-methylpiperazin-l-yl group; with the proviso that when one of R and R is -NO2, then the other is not -NH2; X is O, S or a direct link; Y is an ethylene group optionally substituted by a methyl group; "alk" is an ethylene, trimethylene or tetramethylene group, "alk" being optionally substituted by a methyl group; R is C1-C4 alkyl; and R is H, halo, CF3 or C1-C4 alkyl. The compounds of the formula (A) in which R is -NHSO2R and R is R are antiarrhythmic agents. The remaining compounds of the formula (A) are synthetic intermediates.