PYRIDINYL-CHINOLON-VERBINDUNGEN, IHRE HERSTELLUNG UND VERWENDUNG

Fluorinated 1-cyclopropyl-7-(substituted-pyridinyl)-1,4-dihydro-4-oxo-3-quinolinec arboxylic acids of the formula wherein R is hydrogen, R min and R sec are hydrogen or fluoro, and Z is 3- or 4-pyridinyl substituted by alkyl groups or substituted alkyl groups, are superior antibacterial agents. They...

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Bibliographische Detailangaben
Hauptverfasser:	SINGH,BALDEV,US, DAUM,SOL J.,US, REUMAN,MICHAEL,US, LESHER,GEORGE Y.,US
Format:	Patent
Sprache:	ger
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Fluorinated 1-cyclopropyl-7-(substituted-pyridinyl)-1,4-dihydro-4-oxo-3-quinolinec arboxylic acids of the formula wherein R is hydrogen, R min and R sec are hydrogen or fluoro, and Z is 3- or 4-pyridinyl substituted by alkyl groups or substituted alkyl groups, are superior antibacterial agents. They are prepared via a coupling reaction between the corresponding esters (R = alkyl) having a halo group in the 7-position and a substituted (trialkylstannyl)pyridine.