VERFAHREN ZUR HERSTELLUNG VON DIHYDROPYRIDINDERIVATEN

Novel dihydropyridine derivatives which are useful for treating congestive heart failure, hypertension, and angina have the formula 1: (1) or a pharmaceutically acceptable acid addition salt thereof, wherein: n is an integer from 0 to 8; Y is -O, -NH, -NR2, -S, -S(O), -S(O)2, or a bond; R1 and R2 ar...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	CLARK,ROBIN D.,US, POVZHITKOV,MOYSEY M.,US
Format:	Patent
Sprache:	ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Novel dihydropyridine derivatives which are useful for treating congestive heart failure, hypertension, and angina have the formula 1: (1) or a pharmaceutically acceptable acid addition salt thereof, wherein: n is an integer from 0 to 8; Y is -O, -NH, -NR2, -S, -S(O), -S(O)2, or a bond; R1 and R2 are each independently A1, A2, A3 or A4 where: A1 is -(CH2)m(CHOH)pCH2OH; A2 is -(CH2)qCH(3-r)[(CH2)sOH]r; A3 is -(CH2)qCH(3-r)[(CH2)pCOOR3]r; and A4 is -(CH2)mCOOR3; where: m is an integer from 1 to 8; p is an integer from 0 to 4; q is an integer from 0 to 8; r is 2 or 3; s is an integer from 1 to 4; and R3 is H or alkyl of 1 to 18 carbon atoms; R4 is -NO2, -CF3, or halo; and R5 is lower alkyl or -CH2CH2OCH3.