VERFAHREN ZUR HERSTELLUNG VON BENZOTHIOPHEN-DERIVATEN

Compounds of the formula: (I) and pharmaceutically-acceptable acid addition salts thereof, wherein R1 is at the 3 or 4 position and is phenyl or phenyl substituted by halo, (C1-C4)alkoxy, or (C2-C5)alkoxycarbonyl; R2 is at the 2 or 7 position and is a group of the formula X(CH2)nNR3R4 where X is -CH=CH- or -(CH2)2-; n is 1, 2, 3 or 4; and each of R3 and R4 is hydrogen or (C1-C4)alkyl, or R3 and R4 together with the nitrogen atom to which they are attached form a 1-pyrrolidinyl or piperidino group; Y is hydrogen, (C1-C4)alkyl, (C1-C4)alkoxy or (C2-C5)-alkoxycarbonyl at the 4, 5, 6 or 7 position; and wherein R2 is at the 2-position, R1 is at the 3- or 4-position, or alternatively when R2 is at the 7-position, R1 is at the 3-position; are useful for the treatment of diarrhea in humans and animals.