USE OF PYRIMIDINE DERIVATIVES PER SE OR IN COMBINATION WITH OTHER THERAPEUTIC MEASURES FOR CANCER PREVENTION

Use of a 4-aminopyrimidine derivative (I) or one of its salts for prevention of tumour formation is new. R1 = H, halo, CN, NO2, CF3, NH2, 1-6C alkyl, 1-6C hydroxyalkyl, 1-6C alkoxy, 6-12C aryl, 1-6C alkoxycarbonyl(1-6C) alkyl, 1-6C alkylthio(1-6C)alkyl, 1-6C alkylsulphinyl(1-6C)alkyl, 1-6C alkylsulphonyl(1-6C) alkyl, dihydroxy(1-6C) alkyl, Het1, Ar1, 1-6C alkoxy (substituted by Ar1 or Het1), 1-6C alkoxycarbonylaryl, aryl(1-6C)alkoxy 1-6C alkoxycarbonyl-Ar1, C(O)R6, CH(R7)OY or group of formula (a); Ar1 = aryl (optionally substituted by one or more of X1); X1 = Cl, Br, 1-6C alkyl, 1-6C alkoxy, 1-6C alkylthio, 1-6C alkylsulphinyl, 1-6C alkylsulphonyl, 1-6C hydroxyalkyl or CF3; Het1 = pyridyl, furyl, tetrahydrofuryl, thienyl, imidazolyl, pyrazolyl, triazolyl, thiazolyl, oxazolyl or benzthiazolyl (all optionally substituted by one or more X1); R6 = H, 1-6C alkyl, Ar2 or Het2; Ar2 = aryl (optionally mono-, di- or trisubstituted by X2); X2 = Cl, Br, NO2, CF3, 1-6C alkoxy, 1-6C alkylthio, 1-6C alkylsulphinyl or 1-6C alkylsulphonyl; Het2 = pyridyl, furyl, tetrahydrofuryl, thienyl, imidazolyl, pyrazolyl, triazolyl, thiazolyl, oxazolyl or benzthiazolyl (all optionally mono-, di- or trisubstituted by X2); W, Q, Z = H, 1-6C alkyl or CF3 or phenyl, furyl, triazolyl, thiazolyl or thienyl (all optionally mono-, di- or trisubstituted by 1-6C alkyl, 1-6C alkoxy, CF3 or OH); R7 = Ar3 or Het3; Ar3 = aryl (optionally mono-, di- or trisubstituted by X2 or 1-6C alkyl); Het3 = pyridyl, furyl, thienyl, imidazolyl, pyrazolyl, triazolyl, thiazolyl, oxazolyl, benzthiazolyl, benzofuranyl, benzothienyl or quinolyl (all optionally mono-, di- or trisubstituted by X2 or 1-6C alkyl); Y = H or acetyl or benzyl, benzoyl, phenyl, naphthyl, furyl, thienyl, thiazolyl or oxazolyl (all optionally mono- or disubstituted by X2 or 1-6C alkyl); R2, R3 = H, 1-6C alkyl, Ar4 or Ar4-(1-4C) alkyl; Ar4 = 6-12C aryl (optionally mono-, di- or trisubstituted by Cl, Br, CF3, 1-6C alkyl or 1-6C alkoxy); or NR2R3 = azetidino, pyrrolidino, piperidino, piperazino or morpholino (all optionally mono- or disubstituted by Cl, Br, CF3, 1-6C alkyl, 1-6C alkoxy, 1-6C alkylthio, 1-6C alkylsulphinyl, 1-6C alkylsulphonyl, SO2NH2, SO2NH(1-4C alkyl), SO2N(1-4C alkyl)2, 1-6C alkoxycarbonyl, CONH(1-4C alkyl), CON(1-4C alkyl)2, CONHAr5, COAr6, SO2Ar6, heteroarylcarbonyl or heteroarylsulphonyl; Ar5 = 6-12C aryl (optionally substituted by X3); X3 = 1-4C alkyl, 1-4C alkoxy, halo, NO2, NH2, CN or CF3; Ar6 = 6-12C aryl (substituted