L-GLUTAMIC ACID DERIVATIVE, PROCESS FOR PREPARING THEREOF AND PHARMACEUTICAL PREPARATION IN WHICH SAID DERIVATIVE IS COMPRISED

L-GLUTAMIC ACID DERIVATIVE, PROCESS FOR PREPARING THEREOF AND PHARMACEUTICAL PREPARATION IN WHICH SAID DERIVATIVE IS COMPRISED

This invention relates to N-[2-amino-4-substituted-[[(pyrrolo or pyrido)[2,3-d]pyrimidinyl]-alkyl]benzoyl]-L-glutamic acid compounds of formula wherein Ar is dihydropyrrolo, pyrrolo, pyrido or tetrahydropyrido; R is hydrogen, chloro, alkylthio, alkoxy, alkylamino, or dialkylamino; and R is C2-C3 alk...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: SHIH CHUAN, GOSSETT LYNN STACY
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:This invention relates to N-[2-amino-4-substituted-[[(pyrrolo or pyrido)[2,3-d]pyrimidinyl]-alkyl]benzoyl]-L-glutamic acid compounds of formula wherein Ar is dihydropyrrolo, pyrrolo, pyrido or tetrahydropyrido; R is hydrogen, chloro, alkylthio, alkoxy, alkylamino, or dialkylamino; and R is C2-C3 alkyl intermediates for their synthesis, pharmaceutical formulations containing those compounds, and their use as antineoplastic agents.