ANDROSTANE CARBOTHIOATES
Compounds of the formula < IMAGE > in which R is a fluoro-, chloro- or bromomethyl group or a 2'-fluoroethyl group, R is a group COR in which R is a C1-3-alkyl group, or OR and R together form a 16 alpha ,17 alpha -isopropylidenedioxy group R is a hydrogen atom, a methyl group (which can...
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| creator | LAING STUART BRUCE STEEPLES IAN PHILIP WILLIAMSON CHRISTOPHER PHILLIPS GORDON HANLEY BAIN BRIAN MACDONALD |
| description | Compounds of the formula < IMAGE > in which R is a fluoro-, chloro- or bromomethyl group or a 2'-fluoroethyl group, R is a group COR in which R is a C1-3-alkyl group, or OR and R together form a 16 alpha ,17 alpha -isopropylidenedioxy group R is a hydrogen atom, a methyl group (which can be present in either the alpha or the ss configuration) or a methylene group R is a hydrogen, chlorine or fluorine atom R is a hydrogen or fluorine atom, and the symbol ... is a single or double bond. The compounds have good anti-inflammatory activity, in particular on topical application. The compounds of the formula I are prepared by esterification, halogenation, reduction, elimination of protective groups and reaction at a 9,11 double bond to form a 9 alpha -halo-11ss-hydroxy group. |
| format | Patent |
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The compounds have good anti-inflammatory activity, in particular on topical application. The compounds of the formula I are prepared by esterification, halogenation, reduction, elimination of protective groups and reaction at a 9,11 double bond to form a 9 alpha -halo-11ss-hydroxy group.</description><edition>5</edition><language>eng</language><subject>CHEMISTRY ; CIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTINGELECTRIC POWER ; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER ; ELECTRICITY ; GENERATION ; HUMAN NECESSITIES ; HYGIENE ; MARINE PROPULSION OR STEERING ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PERFORMING OPERATIONS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; RELATED EQUIPMENT ; SHIPS OR OTHER WATERBORNE VESSELS ; STEROIDS ; SYSTEMS FOR STORING ELECTRIC ENERGY ; TRANSPORTING</subject><creationdate>1994</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19940316&DB=EPODOC&CC=CZ&NR=403491A3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19940316&DB=EPODOC&CC=CZ&NR=403491A3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LAING STUART BRUCE</creatorcontrib><creatorcontrib>STEEPLES IAN PHILIP</creatorcontrib><creatorcontrib>WILLIAMSON CHRISTOPHER</creatorcontrib><creatorcontrib>PHILLIPS GORDON HANLEY</creatorcontrib><creatorcontrib>BAIN BRIAN MACDONALD</creatorcontrib><title>ANDROSTANE CARBOTHIOATES</title><description>Compounds of the formula < IMAGE > in which R is a fluoro-, chloro- or bromomethyl group or a 2'-fluoroethyl group, R is a group COR in which R is a C1-3-alkyl group, or OR and R together form a 16 alpha ,17 alpha -isopropylidenedioxy group R is a hydrogen atom, a methyl group (which can be present in either the alpha or the ss configuration) or a methylene group R is a hydrogen, chlorine or fluorine atom R is a hydrogen or fluorine atom, and the symbol ... is a single or double bond. The compounds have good anti-inflammatory activity, in particular on topical application. The compounds of the formula I are prepared by esterification, halogenation, reduction, elimination of protective groups and reaction at a 9,11 double bond to form a 9 alpha -halo-11ss-hydroxy group.</description><subject>CHEMISTRY</subject><subject>CIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTINGELECTRIC POWER</subject><subject>CONVERSION OR DISTRIBUTION OF ELECTRIC POWER</subject><subject>ELECTRICITY</subject><subject>GENERATION</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MARINE PROPULSION OR STEERING</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PERFORMING OPERATIONS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>RELATED EQUIPMENT</subject><subject>SHIPS OR OTHER WATERBORNE VESSELS</subject><subject>STEROIDS</subject><subject>SYSTEMS FOR STORING ELECTRIC ENERGY</subject><subject>TRANSPORTING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1994</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZJBw9HMJ8g8OcfRzVXB2DHLyD_Hw9HcMcQ3mYWBNS8wpTuWF0twM8m6uIc4euqkF-fGpxQWJyal5qSXxzlEmBsYmloaOxsaEVQAAix8fGg</recordid><startdate>19940316</startdate><enddate>19940316</enddate><creator>LAING STUART BRUCE</creator><creator>STEEPLES IAN PHILIP</creator><creator>WILLIAMSON CHRISTOPHER</creator><creator>PHILLIPS GORDON HANLEY</creator><creator>BAIN BRIAN MACDONALD</creator><scope>EVB</scope></search><sort><creationdate>19940316</creationdate><title>ANDROSTANE CARBOTHIOATES</title><author>LAING STUART BRUCE ; STEEPLES IAN PHILIP ; WILLIAMSON CHRISTOPHER ; PHILLIPS GORDON HANLEY ; BAIN BRIAN MACDONALD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CZ403491A33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1994</creationdate><topic>CHEMISTRY</topic><topic>CIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTINGELECTRIC POWER</topic><topic>CONVERSION OR DISTRIBUTION OF ELECTRIC POWER</topic><topic>ELECTRICITY</topic><topic>GENERATION</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MARINE PROPULSION OR STEERING</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PERFORMING OPERATIONS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>RELATED EQUIPMENT</topic><topic>SHIPS OR OTHER WATERBORNE VESSELS</topic><topic>STEROIDS</topic><topic>SYSTEMS FOR STORING ELECTRIC ENERGY</topic><topic>TRANSPORTING</topic><toplevel>online_resources</toplevel><creatorcontrib>LAING STUART BRUCE</creatorcontrib><creatorcontrib>STEEPLES IAN PHILIP</creatorcontrib><creatorcontrib>WILLIAMSON CHRISTOPHER</creatorcontrib><creatorcontrib>PHILLIPS GORDON HANLEY</creatorcontrib><creatorcontrib>BAIN BRIAN MACDONALD</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LAING STUART BRUCE</au><au>STEEPLES IAN PHILIP</au><au>WILLIAMSON CHRISTOPHER</au><au>PHILLIPS GORDON HANLEY</au><au>BAIN BRIAN MACDONALD</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ANDROSTANE CARBOTHIOATES</title><date>1994-03-16</date><risdate>1994</risdate><abstract>Compounds of the formula < IMAGE > in which R is a fluoro-, chloro- or bromomethyl group or a 2'-fluoroethyl group, R is a group COR in which R is a C1-3-alkyl group, or OR and R together form a 16 alpha ,17 alpha -isopropylidenedioxy group R is a hydrogen atom, a methyl group (which can be present in either the alpha or the ss configuration) or a methylene group R is a hydrogen, chlorine or fluorine atom R is a hydrogen or fluorine atom, and the symbol ... is a single or double bond. The compounds have good anti-inflammatory activity, in particular on topical application. The compounds of the formula I are prepared by esterification, halogenation, reduction, elimination of protective groups and reaction at a 9,11 double bond to form a 9 alpha -halo-11ss-hydroxy group.</abstract><edition>5</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY CIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTINGELECTRIC POWER CONVERSION OR DISTRIBUTION OF ELECTRIC POWER ELECTRICITY GENERATION HUMAN NECESSITIES HYGIENE MARINE PROPULSION OR STEERING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES RELATED EQUIPMENT SHIPS OR OTHER WATERBORNE VESSELS STEROIDS SYSTEMS FOR STORING ELECTRIC ENERGY TRANSPORTING |
| title | ANDROSTANE CARBOTHIOATES |
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