ANDROSTANE CARBOTHIOATES

Compounds of the formula < IMAGE > in which R is a fluoro-, chloro- or bromomethyl group or a 2'-fluoroethyl group, R is a group COR in which R is a C1-3-alkyl group, or OR and R together form a 16 alpha ,17 alpha -isopropylidenedioxy group R is a hydrogen atom, a methyl group (which can...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	LAING STUART BRUCE, STEEPLES IAN PHILIP, WILLIAMSON CHRISTOPHER, PHILLIPS GORDON HANLEY, BAIN BRIAN MACDONALD
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY CIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTINGELECTRIC POWER CONVERSION OR DISTRIBUTION OF ELECTRIC POWER ELECTRICITY GENERATION HUMAN NECESSITIES HYGIENE MARINE PROPULSION OR STEERING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES RELATED EQUIPMENT SHIPS OR OTHER WATERBORNE VESSELS STEROIDS SYSTEMS FOR STORING ELECTRIC ENERGY TRANSPORTING
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Beschreibung
Zusammenfassung:	Compounds of the formula < IMAGE > in which R is a fluoro-, chloro- or bromomethyl group or a 2'-fluoroethyl group, R is a group COR in which R is a C1-3-alkyl group, or OR and R together form a 16 alpha ,17 alpha -isopropylidenedioxy group R is a hydrogen atom, a methyl group (which can be present in either the alpha or the ss configuration) or a methylene group R is a hydrogen, chlorine or fluorine atom R is a hydrogen or fluorine atom, and the symbol ... is a single or double bond. The compounds have good anti-inflammatory activity, in particular on topical application. The compounds of the formula I are prepared by esterification, halogenation, reduction, elimination of protective groups and reaction at a 9,11 double bond to form a 9 alpha -halo-11ss-hydroxy group.