AMIDES OF QUINOLYLMETHOXYPHENYLACETIC ACID

AMIDES OF QUINOLYLMETHOXYPHENYLACETIC ACID

Quinolylmethoxyphenyl-acetamides of the formula: rogen, hydroxyl, halogen, cyano, carboxyl, nitro, trifluoromethyl, trifluoromethoxy, alkyl, alkoxy or optionally substituted aryl; R1 represents optionally substituted cycloalkyl; and R2 and R3 independently represent hydrogen, alkyl, benzyl, or optio...

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Hauptverfasser: MATZKE MICHAEL DR, HATZELMANN ARMIN DR, MULLER-PEDDINGHAUS REINER DR, RADDATZ SIEGFRIED DR, MOHRS KLAUS-HELMUT DR, FRUCHTMANN ROMANIS
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Quinolylmethoxyphenyl-acetamides of the formula: rogen, hydroxyl, halogen, cyano, carboxyl, nitro, trifluoromethyl, trifluoromethoxy, alkyl, alkoxy or optionally substituted aryl; R1 represents optionally substituted cycloalkyl; and R2 and R3 independently represent hydrogen, alkyl, benzyl, or optionally substituted cycloalkyl; or together represent piperidinyl, morpholino, or piperazinyl; show a high in vitro activity as leukotriene synthesis inhibitors and, therefore, are suitable for the treatment and prevention of inflammations.