DIPEPTIDE OF L-AZETIDINE-2-CARBOXYLIC ACIDS AND L-ARGININALDEHYDE, PROCESS OF ITS PREPARATION AND PHARMACEUTICAL PREPARATION IN WHICH SAID DIPEPTIDE IS COMPRISED

DIPEPTIDE OF L-AZETIDINE-2-CARBOXYLIC ACIDS AND L-ARGININALDEHYDE, PROCESS OF ITS PREPARATION AND PHARMACEUTICAL PREPARATION IN WHICH SAID DIPEPTIDE IS COMPRISED

Thrombin inhibitors represented by the formula as provided wherein A is e.g. phenylglycyl, and phenylalanyl, a-methylphenylalanine and a-methylphenylglycine wherein the amino group is preferably substituted with lower alkyl alkanoyl or lower alkoxycarbonyl, or a bicyclo group e.g. 1,2,3,4-tetrahydro...

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Bibliographische Detailangaben
1. Verfasser: SHUMAN ROBERT THEODORE
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Thrombin inhibitors represented by the formula as provided wherein A is e.g. phenylglycyl, and phenylalanyl, a-methylphenylalanine and a-methylphenylglycine wherein the amino group is preferably substituted with lower alkyl alkanoyl or lower alkoxycarbonyl, or a bicyclo group e.g. 1,2,3,4-tetrahydroisoquinolin-1-yl. Also provided are a method for inhibiting clot formation in man and animals, pharmaceutical formulations useful in the method and intermediates for the inhibitors.