Substituted benzimidazole homopiperidyl analogs, process of their preparation and pharmaceutical compositions in which the analogs are comprised

Substituované homopiperidylové analogy benzimidazolu obecného vzorce I, jejich N-oxidy, adicní soli, kvarternizované aminy a stereochemicky izomerní formy, kde obecné symboly mají specifický význam. Tyto slouceniny mají relaxacní aktivitu na fundus žaludku a obzvlášte se hodí pro lécení dyspeptických symptomu, syndromu dráždivého tracníku a dalších chorobných stavu se vztahem k omezené nebo zhoršené relaxaci fundu žaludku. Zpusoby prípravy techto analogu a farmaceutické prípravky s jejich obsahem. In the present invention, there are disclosed substituted benzimidazole homopiperidyl analogs of the general formula I, their N-oxides, addition salts, quaternized amines and stereochemically isomeric forms, wherein the general symbols have specific meanings. These compounds exhibit relaxation activity on stomach fundus and they are particularly suitable for treating dyspeptic symptoms, irritable bowel syndrome and other pathological conditions related to a hampered or impaired relaxation of the stomach fundus. Also disclosed are processes for preparing the above-described analogs as well as pharmaceutical compositions in which the analogs are comprised.