Substituted purine derivatives, process of their preparation, use and pharmaceutical preparations in which they are comprised

Purinové deriváty obecného vzorce I, jejich fyziologicky upotřebitelné soli a esterová, acylová a karbamátová profarmaka. Tyto sloučeniny jsou antagonisté vitronektinových receptorů a mohou být použity např. jako inhibitory resorpce kostí a pro léčení osteoporózy.ŕ In the present invention, there are disclosed substituted purine derivatives of the general formula I, physiologically acceptable salts thereof as well as ester, acyl and carbamate prodrugs. These compounds are antagonists of vitronectin receptors and can be therefore used for example as bone resorption inhibitors and for the treatment of osteoporosis.