Novel neuroactive steroids, process of their preparation and use

Nové neuroaktivní steroidy - 3.alfa.-hydroxy-5.alfa.-pregnan-12,20-dion vzorce VI a 3.alfa.-fluor-5.alfa.-pregnan-12,20-dion vzorce VII. Tyto deriváty lze připavit z 3.beta.-hydroxy-5.alfa.-pregnan-12,20-dionu vzorce VIII převedením na aktivní intermediáty, které se rozkládají s inverzí konfigurace buď na zmíněný 3.alfa.-hydroxyderivát vzorce VI nebo na 3.alfa.-fluorderivát vzorce VII a které jsou schopny modulovat .gama.-aminomáselnou kyselinu.ŕ In the present invention, there are disclosed novel neuroactive steroids i.e. û 3{alpha}-hydroxy-5{alpha}-pregnane-12,20-dione of the general formula VI and 3{alpha}-fluoro-5{alpha}-pregnane-12,20-dione of the general formula VII. These derivatives can be prepared from 3{beta}-hydroxy-5{alpha}-pregnane-12,20-dione of the general formula VIII by converting thereof to active intermediates that decompose with configuration inversion either to the said 3{alpha}-hydroxy derivative of the general formula VI or to 3{alpha}-fluoro derivative of the general formula VII and that are capable of modulating {gamma}-aminobutyric acid.