Tetrahydropyridoethers, their use and pharmaceutical preparation in which they are comprised

Tetrahydropyridoethery obecn ho vzorce I, v n m R1 znamen methyl nebo hydroxymethyl, jeden ze substituent R2a a R2b znamen atom vod ku a druh² znamen hydroxyskupinu, methoxy-, ethoxy-, isopropoxy-, methoxyethoxy- nebo methoxypropoxyskupinu, jeden ze substituent R3a a R3b znamen atom vod ku a druh² znamen hydroxyskupinu, methoxy-, ethoxy-, isopropoxy-, methoxyethoxy- nebo methoxypropoxyskupinu, za p°edpokladu, e na jedn stran R2a nebo R2b a na druh stran R3a a R3b neznamenaj sou asn hydroxyskupiny, jako i soli t chto slou enin, jsou l tky s ochrann²m · inkem na alude n a st°evn sliznici a s inhibi n m · inkem na sekreci alude n kyseliny. Jejich pou it pro l en a prevenci gastrointestin ln ch chorob, zejm na z n tliv²ch chorob a v°edov²ch chorob.\ The present invention relates to tetrahydropyridoethers of the general formula I, in which R1 represents methyl or hydroxymethyl, one of the R2a and R2b substituents represents a hydrogen atom and the other represents a hydroxy group, a methoxy, ethoxy, isopropoxy, methoxyethoxy or methoxypropoxy group, one of the R3a and R3b substituents represents a hydrogen atom and the other represents a hydroxy group, a methoxy, ethoxy, isopropoxy, methoxyethoxy or methoxypropoxy group with the proviso that R2a or R2b on one side and R3a and R3b on the other side do not represent simultaneously hydroxy groups, as well as salts of these compounds. The above-described compounds exhibit protective effect to stomach and intestinal mucous membranes and further exhibit inhibition activity on stomach acid secretion. Claimed is also their use for treating and prevention of gastrointestinal diseases, in particular inflammatory and ulcerous diseases.