Oxazolidinone derivative, process of its preparation, its use and pharmaceutical preparation in which the derivative is comprised

Derivát oxazolidinonu obecného vzorce I, kde znamená R.sup.1.n. amidinofenyl popřípadě chráněný skupinou BOC, R.sup.2.n. vodík, A, C.sub.1-10.n.alkanoyl, C.sub.1-8.n.alkoxykarbonyl, benzoyl, naftoyl, C.sub.1-8.n.alkylsulfonyl, benzylsulfonyl nebo fenylsulfonyl, který je popřípadě monosubstituován C.sub.1-6.n.alkylem, R.sup.3.n. atom vodíku nebo C.sub.1-6.n.alkyl, A C.sub.1-16.n.alkyl, a jeho fyziologicky přijatelné soli, jakožto inhibitory integrinu zvláště brzdí vzájemné působení .beta..sub.3.n.- nebo .beta..sub.5.n.-integrinových receptorů s ligandy a jsou vhodné pro výrobu farmaceutických prostředků. Způsob jejich výroby.ŕ In the present invention there is disclosed oxazolidinone derivative of the general formula I, in which Re1 represents amidinophenyl being optionally protected by the BOC group, Re2 represents hydrogen, A alkanoyl containing 1 to 10 carbon atoms, alkoxycarbonyl having 1 to 8 carbon atoms in the alkoxyl moiety, benzoyl, naphthoyl, alkylsulfonyl containing 1 to 8 carbon atoms in the alkyl moiety, benzylsulfonyl or phenylsulfonyl that can be optionally monosubstituted with alkyl having 1 to 6 carbon atoms, Re3 represents a hydrogen atom or alkyl containing 1 to 6 carbon atoms, A represents alkyl containing 1 to 6 carbon atoms, and physiologically acceptable salts thereof inhibit as integrin inhibitors interaction of {beta}i3- or {beta}i5-integrin receptors with ligands and are therefore suitable for preparing corresponding pharmaceutical preparations. The present invention relates also to a process of their preparation.