Salt of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione with pharmaceutically acceptable acid, pharmaceutical preparation containing this substance and use thereof

Salts of substd. thiazolidinedione derivs. of formula (I) and their solvates are new, R1 = H, alkyl, acyl, aralkyl, (opt. ring substd) or opt. substd. aryl; A1 = H or 1-4C substits. from alkyl, alkoxy, aryl or halo or A1 represents 2 substits. on adjacent C atoms which together with the C atoms to w...

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Hauptverfasser: POOL COLIN RIPLEY, TREMPER ALAN WILLIAM, ROMAN ROBIN SHERWOOD, BRIGHTWELL MALCOLM DAVID
Format: Patent
Sprache:cze ; eng
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Zusammenfassung:Salts of substd. thiazolidinedione derivs. of formula (I) and their solvates are new, R1 = H, alkyl, acyl, aralkyl, (opt. ring substd) or opt. substd. aryl; A1 = H or 1-4C substits. from alkyl, alkoxy, aryl or halo or A1 represents 2 substits. on adjacent C atoms which together with the C atoms to which they are attached form an opt. substd. aryl gp.; A2 = benzene opt. substd. by 1-3 substits; M- = a counter ion. 4-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl] thiazolidine-2,4-dione, maleic acid salts is specifically claimed. S l 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidin-2,4-dionu s farmaceuticky p°ijatelnou kyselinou, p°i em touto farmaceuticky p°ijatelnou kyselinou je miner ln kyselina nebo organick kyselina, jin ne kyselina maleinov , nebo tautomern forma t to slou eniny a/nebo farmaceuticky p°ijateln² solv t t to slou eniny. Do rozsahu °e en rovn n le farmaceutick² prost°edek a pou it slou enin podle vyn lezu p°i l en a/nebo profylaxi hyperglyk mie, hyperlipid mie, hypertenze, kardiovaskul rn ch onemocn n a ur it²ch poruch stravovac ch n vyk .\ In the present invention there is disclosed a salt of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione with a pharmaceutically acceptable acid, whereby the pharmaceutically acceptable acid is represented by an inorganic acid or an organic acid other than maleic acid, or a tautomeric form of this compound and/or pharmaceutically acceptable solvate of this compound. In the invention there is also claimed a pharmaceutical preparation and use of the compounds according to the invention for treatment and/or prophylaxis of hyperglycemia, hyperlipidaemia, hypertension, cardiovascular diseases and certain disorders of alimentation addictions.