Cyclopeptide derivative, process of its preparation and pharmaceutical preparations in which it is comprised

In the present invention there is disclosed a cyclopeptide derivative of the general formula I, {Re1-Qe1-X-Qe2-Re2} (I), in which the individual symbols have specific meaning with the proviso that if amino acid radicals and amino acid derivatives are optically active, forms D and L are comprised. Th...

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Hauptverfasser: KESSLER HORST, JONCZYK ALFRED DR, GOODMAN SIMON LAWRENCE, SUTTER ARNE, DIEFENBACH BEATE
Format: Patent
Sprache:eng
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Zusammenfassung:In the present invention there is disclosed a cyclopeptide derivative of the general formula I, {Re1-Qe1-X-Qe2-Re2} (I), in which the individual symbols have specific meaning with the proviso that if amino acid radicals and amino acid derivatives are optically active, forms D and L are comprised. The invented derivative salts, exhibiting activity of integrin inhibitors are therefore suitable for preparing pharmaceutical preparations intended for treating for instance tumor diseases, osteoporosis, osteolytic diseases and for suppression of angiogenesis.