Targeted polymeric cyclosporin conjugates

The structure and the manner of manufacture of polymeric conjugates of cyclosporin, characterized in that they as polymeric carriers contain 40-700 polymerized monomeric units composed from 20-99 % mol. biologically inert hydrophilic units, such as N-(2-hydroxypropyl)methacrylamide, N-vinylpyrrolido...

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Hauptverfasser: RIHOVA BLANKA, FORNUSEK LUBOR, JEGOROV ALEXANDR RNCSC, ULBRICH KAREL, MATHA VLADIMIR CSC, STROHALM JIRI
Format: Patent
Sprache:cze ; eng
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Zusammenfassung:The structure and the manner of manufacture of polymeric conjugates of cyclosporin, characterized in that they as polymeric carriers contain 40-700 polymerized monomeric units composed from 20-99 % mol. biologically inert hydrophilic units, such as N-(2-hydroxypropyl)methacrylamide, N-vinylpyrrolidone, or acrylic and methacrylic acid in the form of sodium salts, 0.1-25 % mol. units of methacryloylated amino acids or methacryloylated oligopeptides with terminally bound cyclosporin and 0-10 % mol. units of methacryloylated amino acids or oligopeptides, with an antibody bound to them as the determinant of transport to the targeted cells.