Selective EP4 receptor agonists intended for treating osteoporosis

Selective EP4 receptor agonists intended for treating osteoporosis

This invention is directed to the use of EP4 receptor selective prostaglandin agonists for the manufacture of a medicament for treating conditions which present with low bone mass, particularly osteoporosis, frailty, an osteoporotic fracture, a bone defect, childhood idiopathic bone loss, alveolar b...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: KE HUAZHU, LEFKER BRUCE ALLEN, CAMERON KIMBERLY O KEEFE, THOMPSON DAVID DUANE
Format: Patent
Sprache:cze ; eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:This invention is directed to the use of EP4 receptor selective prostaglandin agonists for the manufacture of a medicament for treating conditions which present with low bone mass, particularly osteoporosis, frailty, an osteoporotic fracture, a bone defect, childhood idiopathic bone loss, alveolar bone loss, mandibular bone loss, bone fracture, osteotomy, bone loss associated with periodontitis, or prosthetic ingrowth. This invention is especially directed to a use wherein the EP4 receptor selective agonist is a compound of Formula I: wherein the variables are as defined in the specification.e