Derivatives of 3-amino-3-arylpropan-1-ol, process of their preparation, medicaments in which these substances are comprised and their use

3-Amino-3-(hetero)aryl-propan-1-ol derivatives (I) are new. The 3-amino-3-(hetero)aryl-propan-1-ol derivatives are compounds of formula (I), including their enantiomers and diastereoisomers, and their addition salts. A = aryl optionally containing hetero atoms and/or optionally substituted; R , R =...

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Hauptverfasser: HENNIES HAGEN-HEINRICH DR, BUSCHMANN HELMUT DR, KOEGEL BABETTE-YVONNE DR, SUNDERMANN BERND DR
Format: Patent
Sprache:cze ; eng
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Zusammenfassung:3-Amino-3-(hetero)aryl-propan-1-ol derivatives (I) are new. The 3-amino-3-(hetero)aryl-propan-1-ol derivatives are compounds of formula (I), including their enantiomers and diastereoisomers, and their addition salts. A = aryl optionally containing hetero atoms and/or optionally substituted; R , R = 1-6C alkyl; or R + R = form 2-6C alkylidene optionally substituted with phenyl; R = 3-6C alkyl, 3-6C cycloalkyl, aryl (optionally containing hetero atoms and optionally substituted with R -R ) or a group of formula (i); R , R = 1-6C alkyl, 3-6C cycloalkyl, phenyl, benzyl or phenethyl; or R + R = form 3-6C alkylidene or -CH2CH2OCH2CH2-; R -R = H, F, Cl, Br, CHF2, CF3, OH, OCF3, OR , NR R , SR , phenyl, SO2CH3, SO2CF3, 1-6C alkyl, CN, COOR or CONR R ; or R + R = form -OCH2O-, -OCH2CH2O-, -CH=CHO-, -CH=C(CH3)O- or -(CH2)4-; R = 1-6C alkyl, phenyl, benzyl or phenethyl; R , R = H, 1-6C alkyl, phenyl, benzyl or phenethyl; n = 1-3; 1-benzyl-2-(dimethylaminophenylmethyl)cyclohexanol and its reaction product with CH3I are excluded. An Independent claim is also included for the preparation of compounds (I).