PROCESS FOR PREPARING 3BETA-HYDROXYANDROST-5-EN-7,17DIONE FOR MEDICINAL USE

In the present invention there is disclosed a process for preparing 3{beta}-hydroxyandrost-5-ene-7,17-dione (7-oxo-DHEA) of the formula II for medicinal use by allyl oxidation of 17-oxoandrost-5-en-3{beta}-yl ester of the general formula VIII wherein R represents alkyl containing 1 to 5 carbon atoms...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	NOVACEK ALOIS DRSC. CSC, KASAL ALEXANDER RNDRSC
Format:	Patent
Sprache:	cze ; eng
Schlagworte:	CHEMISTRY CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS METALLURGY ORGANIC CHEMISTRY STEROIDS TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	In the present invention there is disclosed a process for preparing 3{beta}-hydroxyandrost-5-ene-7,17-dione (7-oxo-DHEA) of the formula II for medicinal use by allyl oxidation of 17-oxoandrost-5-en-3{beta}-yl ester of the general formula VIII wherein R represents alkyl containing 1 to 5 carbon atoms, for instance dehydroepiandrosterone acetate of the formula IV. Allyl oxidation is carried out by three-day treatment of a diluted oxidation agent at room temperature and followed with subsequent hydrolysis of the protecting group in the oxidation product that is carried out at room temperature, too with a slight excess (1.05 to 1.2 equivalent) of alkali.