DERIVATIVES OF HEXAHYDROPYRROLO /2,3-B/ INDOLE, METHOD OF THEIR PREPARATION AND THEIR APPLICATION AS DRUGS

The present invention relates to compounds of the formula I, where X is O, S, NH, N-loweralkyl, or N-arylloweralkyl; Y is hydrogen, fluorine, chlorine, bromine, nitro, loweralkyl, loweralkoxy, or triloweralkylsilyl; R1 is loweralkyl, halogen-substituted loweralkyl, aryl, arylloweralkyl, cycloalkyl,...

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Bibliographische Detailangaben
Hauptverfasser:	OOMALLEY GERALD JOSEPH,US, WHITE JOHN IRVING,US, ALLEN RICHARD CHARLES,US
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to compounds of the formula I, where X is O, S, NH, N-loweralkyl, or N-arylloweralkyl; Y is hydrogen, fluorine, chlorine, bromine, nitro, loweralkyl, loweralkoxy, or triloweralkylsilyl; R1 is loweralkyl, halogen-substituted loweralkyl, aryl, arylloweralkyl, cycloalkyl, heteroaryl or heteroarylloweralkyl; R2 is hydrogen, loweralkyl or arylloweralkyl; R3 is loweralkyl or arylloweralkyl; R4 is hydrogen, loweralkyl, loweralkenyl, loweralkynyl, arylloweralkyl, formyl, loweralkylcarbonyl, arylloweralkylcarbonyl or loweralkoxycarbonyl; R5 is hydrogen or loweralkyl; and m is 0 or 1, with the proviso that when m is 0, R1 may also be hydrogen, and a process for their preparation. The compounds of the invention are useful for alleviating various memory dysfunctions characterized by a cholinergic deficit such as Alzheimer's disease.