METHOD OF 3-(4-CYANO-4-PHENYLALKYL)TETRAHYDROISOQUINOLINE DERIVATIVES PRODUCTION

METHOD OF 3-(4-CYANO-4-PHENYLALKYL)TETRAHYDROISOQUINOLINE DERIVATIVES PRODUCTION

Compounds of the formula (1) wherein R1 and R2 are each independently -H or lower alkoxy; R3 and R4 are each independently lower alkyl; and R5 and R6 are each -OCH3, or together form -OCH2O- or -OCH2CH2O- and pharmaceutically acceptable acid addition salts thereof are calcium channel blockers useful...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MUCHOWSKI JOSEPH M.,US, CHIU FANG-TING,US, BERGER JACOB,US, GARDNER JOHN O.,US, CLARK ROBIN D.,US
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Compounds of the formula (1) wherein R1 and R2 are each independently -H or lower alkoxy; R3 and R4 are each independently lower alkyl; and R5 and R6 are each -OCH3, or together form -OCH2O- or -OCH2CH2O- and pharmaceutically acceptable acid addition salts thereof are calcium channel blockers useful for treating cardiovascular disorders including angina, hypertension and congestive heart failure.