METHOD OF COAGULATIVE FACTORS' CONCENTRATES PREPARATION FROM BLOOD PLASMA

METHOD OF COAGULATIVE FACTORS' CONCENTRATES PREPARATION FROM BLOOD PLASMA

Concentrates of blood coagulation factors II, VII, IX and/or X are new, obtainable by contacting a biological material contg. the factors with a sorbent based on DEAE-poly(hydroxyethyl acrylate) and/or DEAE-poly(hydroxyethyl methacrylate) i.e. DEAE-HE(M)A), and desorption with a buffer soln. of pH 7...

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Hauptverfasser: LOSTICKY CYRIL RNCSC.,CS, KASAFIREK EVZEN CSC.,CS, SEDLMAIER OLDRICH,CS, ULRYCH STANISLAV RNDR.,CS, RYBAK MIROSLAV CSC.,CS
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Concentrates of blood coagulation factors II, VII, IX and/or X are new, obtainable by contacting a biological material contg. the factors with a sorbent based on DEAE-poly(hydroxyethyl acrylate) and/or DEAE-poly(hydroxyethyl methacrylate) i.e. DEAE-HE(M)A), and desorption with a buffer soln. of pH 7.2-7.6 with saline concn. 0.3-2.0M. - Also claimed are methods and compsns. for qualitative and quantitative determination of factor VII in biological materials, using concentrates of factors II and X, pref. prepd. as above.