ZPUSOB VYROBY DERIVATU KYSELINY 16 FENOXYPROSTATRIENOVE

This invention relates to a process for making a compound of formula Iin the form of a stereoisomer or mixture thereof, wherein R is hydrogen, lower alkyl; X is hydrogen, halo, trifluoromethyl, lower alkyl or lower alkoxy, and the wavy lines represent the a or β configuration with the proviso that w...

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Hauptverfasser: VAN HORN ALBET R.,US, COOPER GARY F.,US, LI TSUNG TEE,US, WREN DOUGLAS L.,US, BEARD COLINS CH.,US
Format: Patent
Sprache:eng
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Zusammenfassung:This invention relates to a process for making a compound of formula Iin the form of a stereoisomer or mixture thereof, wherein R is hydrogen, lower alkyl; X is hydrogen, halo, trifluoromethyl, lower alkyl or lower alkoxy, and the wavy lines represent the a or β configuration with the proviso that when one wavy line is α the other is β, or a pharmaceutically acceptable, non-toxic salt of the compound wherein R is hydrogen; novel intermediates useful for preparing these compounds; processes for making the intermediates; and a stereoisomer of the compound of formula I wherein R is methyl and X is hydrogen and a process for making same.