2-SUBSTITUTED QUINOLINES, PROCESS OF THEIR PREPARATION AND THEIR USE INMEDICAMENTS

2-SUBSTITUTED QUINOLINES, PROCESS OF THEIR PREPARATION AND THEIR USE INMEDICAMENTS

2-substituted quinolines of the general formula The title compounds are prepared by reacting either the corresponding halomethylquinolines with substituted phenols, then optionally alkylating these and hydrolysing esters to acids, or by reacting phenyl-substituted quinolinecarboxylic acid derivative...

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Hauptverfasser: MATZKE MICHAEL DR, HATZELMANN ARMIN DR, MULLER-PEDDINGHAUS REINER DR, RADDATZ SIEGFRIED DR, THEISEN-POPP PIA DR, MOHRS KLAUS-HELMUT DR, KOHLSDORFER CHRISTIAN DR, FRUCHTMANN ROMANIS
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:2-substituted quinolines of the general formula The title compounds are prepared by reacting either the corresponding halomethylquinolines with substituted phenols, then optionally alkylating these and hydrolysing esters to acids, or by reacting phenyl-substituted quinolinecarboxylic acid derivatives with sulphonamides. The novel phenyl-substituted quinolines can be used as active compounds in medicaments, in particular as lipoxygenase inhibitors.