PROCESS FOR PREPARING 1-/HYDROXYSTYRYL/-5H-2,3-BENZODIAZEPINES

This invention relates to new 1-(hydroxystyryl)-5H-2,3-benzodiazepine derivatives of the general formula (I) and to a process for the preparation thereof, furthermore to pharmaceutical compositions containing the same, (I) wherein R stands for a hydrogen or halogen atom, or a C1-4 alkoxy group, R1 r...

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Bibliographische Detailangaben
Hauptverfasser:	HAMORI TAMAS,HU, KUHAR MARIA,HU, HELTAI KRISZTINA DR.,HU, ZOLYOMI GABOR DR.,HU, POLGARI ISTVAN DR.,HU, ELEKES ISTVAN DR.,HU, SAROSSY JUDIT,HU, KOROSI JENO DR.,HU, LANG TIBOR DR.,HU, MORAVCSIK IMRE,HU, RABLOCZKY GYORGY DR.,HU, LANG ZSUZSANNA DR.,HU
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	This invention relates to new 1-(hydroxystyryl)-5H-2,3-benzodiazepine derivatives of the general formula (I) and to a process for the preparation thereof, furthermore to pharmaceutical compositions containing the same, (I) wherein R stands for a hydrogen or halogen atom, or a C1-4 alkoxy group, R1 represents a hydrogen atom or a C1-4 alkyl group, R2 and R3 are identical and denote a C1-4 alkyl group, or combined they denote a methylene group. The compounds of the general formula (I) possess valuable positive inotropic (cardiotonic) potency, are capable to increase the myocardiac contractile force (heart performance in cardiac insufficiency), thus they can be applied in the therapy of chronic heart failure and coronary ailments.