METHOD OF OPTICALLY ACTIVE TRANS-(-)-1 BETA-ETHYL-1 ALPHA-HYDROXYMETHYL-1,2,3,4,6,7,12,12B ALPHA-OCTAHYDROINDOLO/2,3-A/ QUINOLIZINE PREPARATION

The invention relates to the new (-)-1 beta -ethyl-1 alpha -hydroxymethyl-1,2, 3,4,6,7,12,12b alpha -octa-hydroindolo[2,3-a] quinolizine of the formula (I) (I) and acid addition salts thereof. According to another aspect of the invention there is provided a process for the preparation of the compoun...

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Hauptverfasser:	CSOMOR KATALIN,HU, LASZLOVSZKY ISTVAN DR.,HU, SZANTAY CSABA ,HU, SZOMBATHELYI ZSOLT DR.,HU, FORGACS LILLA DR.,HU, LAPIS ERZSEBET ,HU, KUTHI CSABA ,HU, KARPATI EGON DR.,HU, GERE ANIKO,HU, SZABO LAJOS DR.,HU, KISS BELA,HU, SZPORNY LASZLO DR.,HU, KALAUS GYORGY ,HU
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to the new (-)-1 beta -ethyl-1 alpha -hydroxymethyl-1,2, 3,4,6,7,12,12b alpha -octa-hydroindolo[2,3-a] quinolizine of the formula (I) (I) and acid addition salts thereof. According to another aspect of the invention there is provided a process for the preparation of the compound of formula (I) and acid addition salts thereof by resolution of the corresponding racemic compound and optionally by subsequent hydrolysis and/or salt formation. The compound of formula (I) shows a remarkable peripheral vasodilating and antihypoxial activity. Pharmaceutical compositions comprising it as active ingredient are also within the scope of the invention.