OXADIAZOLYLALKYLPURINE DERIVATIVES, PROCESSES OF THEIR PREPARATION AND PHARMACEUTICALS COMPRISING THEREOF

The invention relates to new oxidiazole-alkyl-purine-derivatives of the Formula I and pharmaceutically acceptable salts thereof wherein A stands for C1-4 alkylene and R1 represents C1-6 alkyl, hydroxyalkyl, halogenoalkyl, carboxyalkyl, C5-6 cycloalkyl or aminoalkyl of the Formula -(CH2)n-NR2R3 in wh...

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Bibliographische Detailangaben
Hauptverfasser:	MARMAROSI KATALIN, GOTTSEGEN AGNES, BOLEHOVSZKY ANDREA, MINKER EMIL DR, KORBONITS DEZSO, DEBRECZENI LORAND DR, HORVATH GABOR DR, KORMOCZY PETER DR, ANTUS SANDOR, KOVACS GABOR, GERGELY VERA DR, VARGAI ZOLTAN DR, HEJA GERGELY, TARDOS LASZLO DR, VIRAG SANDOR DR, MARTON JENO DR
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to new oxidiazole-alkyl-purine-derivatives of the Formula I and pharmaceutically acceptable salts thereof wherein A stands for C1-4 alkylene and R1 represents C1-6 alkyl, hydroxyalkyl, halogenoalkyl, carboxyalkyl, C5-6 cycloalkyl or aminoalkyl of the Formula -(CH2)n-NR2R3 in which group n is an integer 1-3; R2 and R3 each stand for hydrogen or C1-4 alkyl or together with the adjacent nitrogen atom they are attached to form a 5- or 6-membered nitrogen containing heterocyclic ring which may optionally comprise a further nitrogen atom or an oxygen atom as heteroatom; or R1 stands for phenyl, hydroxyphenyl, carboxyphenyl, benzyl or dimethoxybenzyl The compounds of the Formula I can be prepared by methods known per se and can be used in therapy as antitussive agents.