METHOD OF 4-ALKOXY-3-PYRROLINE-2-ON-1-YL ACETIC ACID'S ALKYL ESTERS PRODUCTION

The method of production of alkylesters of 4-alkoxy-3-pyrroline-2-one-1-ylacetic acid, which contain from 1 to 4 carbon atoms in alkyl part of alkyl ester and 1 or 2 carbon atoms in alkoxyl part of the acid, consists in the fact that the alkyl ester of 4-halogen-3-alkoxy-2-E-butenic acid, in which the alkyl part of the alkyl ester contains 1 or 2 carbon atoms, is introduced into a reaction with glycine alkyl ester, in which the alkyl part contains from 1 to 4 carbon atoms, in presence of weak inorganic base or tertiary aliphatic amine in presence of polar protic or aprotic solvent at a temperature of 60 to 120 degrees C. These products are valuable as intermediary products for production of cerebrally effective 4-hydroxy-2-oxopyrrolidine-1-ylacetamide.