METHOD OF 2-/4-(2-PROPYLTHIO)PHENYL/PROPIONIC ACID'S PREPARATION

The solution falls with the branch of synthesis of pharmaceuticals. Its principle consists in method of preparation of 2-(4-(2-propylthio)phenyl)propionic acid. This substance is characteristic by its antiphlogistic and analgesic effects and can be used practically in pharmacotherapy. In comparison...

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Hauptverfasser:	MATUROVA EVA MUDR.,CS, SINDELAR KAREL CSC.,CS, GRIMOVA JAROSLAVA MUCSC.,CS, PROTIVA MIROSLAV DRSC.,CS, JILEK JIRI RNDRSC.,CS
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The solution falls with the branch of synthesis of pharmaceuticals. Its principle consists in method of preparation of 2-(4-(2-propylthio)phenyl)propionic acid. This substance is characteristic by its antiphlogistic and analgesic effects and can be used practically in pharmacotherapy. In comparison with generally known ibuprofen (registered trademark) it has comparable antiphlogistic effect and gastrotoxicity. Its advantages consist in higher analgesic effect and lower acute toxicity in mice administered orally. The preparation method of the substance I according to the solution consists in reaction of 2-(4-mercaptophenyl)propionic acid with 2-brompropane in dimethylformamide in presence of potassium carbonate at a temperature of 50 to 80 degrees C and in subsequent hydrolysis of non-characterised intermediary product by boiling solution of sodium hydroxide in aqueous ethanol.