METHOD OF 2-/P-AMINOBENZENSULPHONYLAMINO/ PYRIDINE PRODUCTION

The invention concerns a method of production of the chemotherapeutic 2-(p-aminobenzensulphonylamino)pyridine, which has recently become an important intermediate product for production of medicaments with antipyretic and analgesic effect. It was prepared by reaction of 2 moles p-acetyl-aminobenzene...

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Bibliographische Detailangaben
Hauptverfasser:	DUNDR VLADIMIR ,CS, HROMAS JOSEF ,CS, NOVACEK ALOIS DOC. DRSC.,CS, SEDLACKOVA VENUSE ,CS, KORNER JAROSLAV ,CS
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	The invention concerns a method of production of the chemotherapeutic 2-(p-aminobenzensulphonylamino)pyridine, which has recently become an important intermediate product for production of medicaments with antipyretic and analgesic effect. It was prepared by reaction of 2 moles p-acetyl-aminobenzene-sulphonyl chloride with 1 mole 2-aminopyridine in the presence of sodium hydro-carbonate in an aqueous environment and subsequent reaction with an aqueous solution of sodium hydroxide.