METHOD OF 4-BENZYLOXY-3-PYRROLINE-2-ON-1-YL-ACETAMIDE PRODUCTION

4-benzyloxy-3-pyrroline-2-on-1-ylacetamide, is a suitable semi-product for the production of pharmaceutically efficient 4-hydroxypyrrolidine-2-on-1-ylacetamide is obtained through a reaction of 4-alkoxy-3-pyrroline-2-on, where the alkoxyl part contains 1 to 4 carbon atoms, with benzyl alcohol in the presence of a catalytic amount of acid at a temperature of 60 to 100 degrees C to 4-benzyloxy-3-pyrroline-2-on, which is alkylated by alkyl ester of a 2-bromoacetic acid, in which the alkyl part contains 1 to 4 carbon atoms, at a temperature of 0 to 40 degrees C in the presence of an alkaline metal hydride to alkyl ester of 4-benzyloxy-3-pyrroline-2-on-1-yl-acetic acid, in which the alkyl part of the alkyl ester contains 1 to 4 carbon atoms and this one is left to react with the ammoniac at a temperature of 60 to 80 degrees C of the final product.