PROCESS FOR PREPARING 2-SUBSTITUTED 1,3-PROPYLIDENDIPHOSPHONATES

PROCESS FOR PREPARING 2-SUBSTITUTED 1,3-PROPYLIDENDIPHOSPHONATES

2-Substituted-1,3-propylidenediphosphonates of formula (I), where A, R1 and R2 are defined in claim 1, are therapeutically active compounds, namely for the treatment of cardiovascular diseases. They can be prepared by reacting phosphonating agents with 1,3- dibromopropanes or ditosylates of 1,3-prop...

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Bibliographische Detailangaben
Hauptverfasser: PHAN HIEU T.,CH, BENTZEN GRAIG L. CHAVANNES-DE-BOGIS,CH, ROSSIER JEAN-ROBERT,CH, KALATHAKIS KYRIACOS,CH, NQUYEN MONG L.,CH, GUYON-GELLIN V.,FR, NIESOR ERIC,CH
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:2-Substituted-1,3-propylidenediphosphonates of formula (I), where A, R1 and R2 are defined in claim 1, are therapeutically active compounds, namely for the treatment of cardiovascular diseases. They can be prepared by reacting phosphonating agents with 1,3- dibromopropanes or ditosylates of 1,3-propanediols substituted in position 2. (I) .