METHOD OF EBURNAMENINE'S RACEMIC AND OPTICALLY ACTIVE DERIVATIVES' TRANSSTEREOISOMERS PRODUCTION

METHOD OF EBURNAMENINE'S RACEMIC AND OPTICALLY ACTIVE DERIVATIVES' TRANSSTEREOISOMERS PRODUCTION

The invention relates to the preparation of cis and trans stereoisomers of racemic and optically active eburnamenine derivatives of the general formula (Ia) (Ia) or (Ib), (Ib) wherein R1 stands for a C1-4 alkyl group; and R stands for hydrogen, a C1-6 alkyl group, a C2-6 alkenyl group, an acyl or su...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: SZOMBATHELYI,ZSOLT,HU, FORGACS,LILLA,HU, KUTHI,CSABA,HU, SZPORNY,LASZLO,HU, KREIDL,JANOS,HU, VISKY,GYOERGY,HU, FARKAS,MARIA,HU, KARPATI,EGON,HU, CSOMOR,KATALIN,HU, GERE,ANIKO,HU, CZIBULA,LASZLO,HU, KISS,BELA,HU, STEFKO,BELA,HU
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The invention relates to the preparation of cis and trans stereoisomers of racemic and optically active eburnamenine derivatives of the general formula (Ia) (Ia) or (Ib), (Ib) wherein R1 stands for a C1-4 alkyl group; and R stands for hydrogen, a C1-6 alkyl group, a C2-6 alkenyl group, an acyl or substituted acyl group, as well as their acid addition salts, of which the trans compounds are novel. The invention also relates to the compounds of the general formula (IIIa) (IIIa) and (IIIb), (IIIb) wherein R1 and R' represent a C1-4 alkyl group. The compounds of the general formulae (Ia) and (Ib) possess a vasodilatory effect which is substantially higher than that of pentoxifyllin, a known peripheral vasodilator.