METHOD OF MAKING THE NEW 4-SUBSTITUTED DERIVATIVES OF DAUNORUBICINE

METHOD OF MAKING THE NEW 4-SUBSTITUTED DERIVATIVES OF DAUNORUBICINE

Compounds of the formula: wherein R1 is a C2-C4 alkyl; a C3-C6 cycloalkyl or benzyl; A and B are OH or A and B are OCOOR4 or B is OH and A is OCOOR4; and R4 is alkyl which are intermediates for the preparation of antitumor compounds of the formula: I wherein R1 is a C2-C4 alkyl; a C3-C6 cycloalkyl;...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MASI,PAOLO,IT, ARCAMONE,FEDERICO,IT, BERNARDI,LUIGI,IT, SUARATO,ANTONINO,IT
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Zusammenfassung:Compounds of the formula: wherein R1 is a C2-C4 alkyl; a C3-C6 cycloalkyl or benzyl; A and B are OH or A and B are OCOOR4 or B is OH and A is OCOOR4; and R4 is alkyl which are intermediates for the preparation of antitumor compounds of the formula: I wherein R1 is a C2-C4 alkyl; a C3-C6 cycloalkyl; a C3-C6 cycloalkyl substituted by a halogen, hydroxy, methoxy, amino or dimethylamino group; phenyl or phenyl substituted with nitro, chlorine or methoxy thiazyl, pyridyl, pyrazyl; or a phenyl-alkyl group of the formula X-Phe-(CH2)n-, in which X is hydrogen, halogen, hydroxyl, amino, or nitro and n is an integer from 1 to 2; R2 is hydrogen, hydroxyl or acyloxy (R-COO-); where R is an alkyl having from 1 to 11 carbon atoms; and R3 is hydrogen or trifluoroacetyl and salts thereof with pharmaceutically acceptable acids.