METHOD OF MAKING THE (+) 3A, 7A-TRANS-4-/7,7-/ETHYLENEDIOXY /-OXOOKTYL/-7A BETA-METHYLPERHYDROINDANE-1,5-DION

(A process for preparing steroid intermediates of the formula in which pivaloyl chloride is added to a compound of the formula the resulting compound of the formula is reacted with a Grignard reagent of the formula wherein X is Cl or Br, and the resulting compound of the formula is cyclized in the p...

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Bibliographische Detailangaben
Hauptverfasser:	COOPER,GARY F.,US, VAN HORN,ALBERT R.,US
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES STEROIDS
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Beschreibung
Zusammenfassung:	(A process for preparing steroid intermediates of the formula in which pivaloyl chloride is added to a compound of the formula the resulting compound of the formula is reacted with a Grignard reagent of the formula wherein X is Cl or Br, and the resulting compound of the formula is cyclized in the presence of a base. Compound I in turn may be readily converted by known methods to valuable steroids. Disclosed as a mixed anhydride steroid intermediate of formula III is 7a beta -methyl-2,3,3a alpha , 4, 5, 6, 7; 7a-octahydro-1H-inden-1,5-dione-4 alpha -(3-propionic acid) pivalic acid mixed anhydride.)