METHOD OF PREPARING IMIDAZOLYL COMPOUNDS

Procedure to prepare anti-histamine compounds, of formula: **(See formula)** where n is 2 or 3; 2 is sulfur or methylene; X ex sulfur, CHNO2 or NCH; Y is hydrogen, lower alkyl, or Het CH2Z'(CH2) n', where Het is 5-Mdroxymethyl-4-imidazolyl or is an imidazole ring optionally substituted by methyl or bromine, a pyridine ring optionally substituted by hydroxy, methoxy, chlorine or bromine, a thiazolyl ring, or an isothiazolyl ring; Z'is sulfur or methylene; and n'is 2 or 3, characterized in that it comprises reacting a compound of formula: **(See formula)** where X is NCN or CHNO2, Q is lower alkyl, B is SQ', OQ', where Q'is lower alkyl, or NHY, where Y is defined as above, and A is sulfur, oxygen or when X is CHNO2 and B is SQ', SO, with a compound of the formula: **(See formula)** where Z is sulfur or methylene and n is 2 or 3. (Machine-translation by Google Translate, not legally binding)