METHOD OF PREPARING ARYLOXYALKYL AMINOBENZOIC ACIDS AND ESTERS THEREOF

Procedure for the preparation of aryloxyalkylaminobenzoz acids and esters, of formula ** (Formula) ** where Y is straight or branched chain alkyl, CnH2n where n is 2 to 12; R1 is hydrogen, lower alkyl, 0, 2, 3-dihydroxypropyl; X is phenyl, naphthyl, thienyl, furyl, 1,2,3,4-tetrahydronaphthyl, 4-chloro-1-naphthyl, or substituted phenyl, wherein the phenyl substituents are halogen, hydroxyl, lower alkoxy, lower aralkyl, cyano, trihalomethyl, amino, lower alkanoylamino, lower alkylamino, dialkylamino lower, phenoxy, p-chlorophenoxy, benzyl-p-chlorobenzyloxy or cycloalkyl; and when R1 is hydrogen, the alkali metal salts or organic bases thereof; characterized in that it comprises reacting a lower alkyl p-aminobenzoate, p-aminobenzoic acid, or other ester of p-aminobenzoic acid with an alkylating agent, with or without a solvent, at 50º to 170ºC for 1 to 25 hours. (Machine-translation by Google Translate, not legally binding)