INHIBIDORES MACROCICLICOS DEL VIRUS DE LA HEPATITIS C

Inhibidores de la replicacion del VHC de formula (I) y los N-oxidos, sales y estereoisomeros, donde cada linea punteada representa un doble enlace opcional; X es N, CH y cuando X posee un doble enlace es C; R1 es -OR7, -NH-SO2R8; R2 es hidrogeno y cuando X es C o CH, R2 tambien puede ser alquilo C1-6; R3 es hidrogeno, alquilo C1-6-alquilo C1-6, cicloalquilo C3-7; R4 es arilo O Het, n es 3, 4, 5 o 6; R5 es halo, alquilo C-6, hidroxi, alcoxi C1-6, fenilo o Het; R6 es alcoxi C1-6 o dimetilamino; R7 es hidrogeno; arilo; Het; cicloalquilo C3-7 sustituido opcionalmente con alquilo C1-6; o alquilo C1-6 sustituido opcionalmente con cicloalquilo C3-7, arilo o con Het; R8 es arilo; Het. Combinations comprising inhibitors of HCV replication of formula (I) and the N -oxides, salts, and stereoisomers, wherein each dashed line represents an optional double bond; X is N, CH and where X bears a double bond it is C; R 1 is -OR 7 , -NH-SO 2 R 8 ; R 2 is hydrogen, and where X is C or CH, R 2 may also be C 1-6 alkyl; R 3 is hydrogen, C 1-6 alkyl, C 1-6 alkoxyC 1-6 alkyl, C 3-7 cycloalkyl; R 4 is aryl or Het; n is 3, 4, 5, or 6; R 5 is halo, C 1-6 alkyl, hydroxy, C 1-6 alkoxy, phenyl, or Het; R 6 is C 1-6 alkoxy, or dimethylamino; R 7 is hydrogen; aryl; Het; C 3-7 cycloalkyl optionally substituted with C 1-6 alkyl; or C 1-6 alkyl optionally substituted with C 3-7 cycloalkyl, aryl or with Het; R 8 is aryl; Het; C 3-7 cycloalkyl optionally substituted with C 1-6 alkyl; or C 1-6 alkyl optionally substituted with C 3-7 cycloalkyl, aryl or with Het; aryl is phenyl optionally substituted with one, two or three substituents; Het is a 5 or 6 membered saturated, partially unsaturated or completely unsaturated heterocyclic ring containing 1 to 4 heteroatoms selected from nitrogen, oxygen and sulfur, and being optionally substituted with one, two or three substituents.