FORMAS DE DOSIFICACION DE AZITROMICIDA CON EFECTOS SECUNDARIOS REDUCIDOS

Una forma de dosificacion oral que comprende azitromicina y una cantidad eficaz de un agente alcalinizante. Preferiblemente, dicha forma de dosificacion oral comprende una cantidad eficaz de un agente alcanizante y un multiparticulado de azitromicina en el que dicho multiparticulado comprende azitromicina, una mezcla de monobehenato de glicerilo, dibehenato de glicerilo y tribehenato de glicerilo y un poloxamero. Tipicamente, la forma de dosificacion oral incluye cualquier medio deadministracion oral adecuado tal como un polvo para suspension oral, un envase o sobrecito de dosis unitaria, un comprimido o una capsula. An oral dosage form comprising azithromycin and an effective amount of an alkalizing agent. Preferably, said oral dosage form comprises an effective amount of an alkalizing agent and an azithromycin multiparticulate wherein said multiparticulate comprises azithromycin, a mixture of glyceryl monobehenate, glyceryl dibehenate and glyceryl tribehenate, and a poloxamer. Typically, the oral dosage form includes any suitable oral dosing means such as a powder for oral suspension, a unit dose packet or sachet, a tablet or a capsule. Additionally disclosed is an oral suspension comprising azithromycin, an effective amount of an alkalizing agent and a vehicle. Preferably, the azithromycin is in multiparticulate form wherein said multiparticulate comprises azithromycin, a mixture of glyceryl monobehenate, glyceryl dibehenate and glyceryl tribehenate, and a poloxamer. Also disclosed is a method for reducing gastrointestinal side effects, associated with administering azithromycin to a mammal, comprising contiguously administering azithromycin and an effective amount of alkalizing agent to said mammal wherein the frequency of gastrointestinal side effects is lower than that experienced by administering an equal dose of azithromycin without said alkalizing agent. Further disclosed is a method of treating a bacterial or protozoal infection in a mammal in need thereof comprising contiguously administering to said mammal a single dose of an oral dosage form wherein said oral dosage form comprises azithromycin and an effective amount of an alkalizing agent. Additionally disclosed are azithromycin multiparticulates comprising azithromycin, a surfactant; and a pharmaceutically acceptable carrier.