ANTIBODY VARIANT AND ISOFORM WITH LOWERED BIOLOGICAL ACTIVITY

As an antibody variant and isoform having a lower FVIII-like activity than emicizumab, provided are an antibody variant (Q-CDR-clipped variant) in which a specific amino acid residue in a variable region is cleaved and deleted, and an antibody isoform (protected disulfide isoform) in which a disulfi...

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Hauptverfasser:	TANAKA, Nobuyuki, FUKUDA, Masakazu, KUWAYAMA, Maki, WATANABE, Yosuke, SEIDA, Chifumi, SAITOH, Satoshi, HOSOGUCHI, Kensaku
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPIRITS TESTING VINEGAR WINE
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Zusammenfassung:	As an antibody variant and isoform having a lower FVIII-like activity than emicizumab, provided are an antibody variant (Q-CDR-clipped variant) in which a specific amino acid residue in a variable region is cleaved and deleted, and an antibody isoform (protected disulfide isoform) in which a disulfide bond between heavy chains is hardly reduced under mild reduction conditions. Variantes e isoformas de anticuerpos que tienen una actividad mimética de FVIII reducida en comparación con el Emicizumab, en donde las variantes de los anticuerpos tienen algunos residuos de aminoácido específicos en la región variable escindidos y faltantes (Variantes con corte de Q-CDR), y las isoformas de anticuerpo tienen puentes disulfuro entre las cadenas pesadas que son menos susceptibles a la reducción bajo condiciones reductoras suaves (Isoformas de Disulfuros Protegidos)