INHIBITORS OF NLRP3

The present invention relates to novel compounds of Formulae I-XI: wherein each A, A', Q, Q', W, Rw, Y, and Z, and -- are as defined herein, which inhibit NOD-like receptor protein 3 (NLRP3) inflammasome activity. The invention further relates to the processes for their preparation, pharma...

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Hauptverfasser: BEJCEK, Lauren, HOSSEYNI, Seyedmorteza, SYDORENKO, Nadiya, PILLAI, Meenu, ZHANG, Nanjing, HUARTE, Eduardo, GONG, Hua, Handoko, LI, Jing, BARRAZA, Scott, J, WOLL, Matthew, G, PARKER, Erica, N, ALAM, Rauful, GILBERT, Bradley, B, NIEDERER, Kyle, ZHENG, Tianyi, ZHANG, Xiaoyan, TURPOFF, Anthony, JEON, Woohyung, LIU, Yao, ZHANG, Yan, RASTELLI, Ettore
Format: Patent
Sprache:eng ; spa
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Zusammenfassung:The present invention relates to novel compounds of Formulae I-XI: wherein each A, A', Q, Q', W, Rw, Y, and Z, and -- are as defined herein, which inhibit NOD-like receptor protein 3 (NLRP3) inflammasome activity. The invention further relates to the processes for their preparation, pharmaceutical compositions and medicaments containing them, and their use in the treatment of diseases and disorders mediated by NLRP3. La presente invención se refiere a nuevos compuestos de fórmulas I-XI: en donde cada A, A', Q, Q', W, Rw, Y y Z, y -- son como se definen en el presente documento, que inhiben la actividad del inflamasoma NLRP3 (proteína 3 receptora tipo NOD). La invención también se refiere a los procesos para su preparación, a composiciones farmacéuticas y medicamentos que los contienen y a su uso en el tratamiento de enfermedades y trastornos mediados por NLRP3.