NOVEL RNA THERAPEUTICS AND USES THEREOF

The present disclosure relates to novel RNAi agents designed to decrease the expression of ANGPTL8 in the liver, where the RNAi agents comprise delivery moieties conjugated to oligonucleotides optionally via a linker. The RNAi agents are useful in the treatment of diseases involving the regulation o...

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Bibliographische Detailangaben
Hauptverfasser:	EGGEN, MariJean, BELLINGER, Melissa, Ann, WILSON, Takako, CHENG, Christine, Chih-Tao, MILES, Rebecca, Ruth, LACKNER, Gregory, Lawrence, WANG, Jibo, ANTONELLIS, Patrick, Joseph, BEYER, Thomas, Patrick
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present disclosure relates to novel RNAi agents designed to decrease the expression of ANGPTL8 in the liver, where the RNAi agents comprise delivery moieties conjugated to oligonucleotides optionally via a linker. The RNAi agents are useful in the treatment of diseases involving the regulation of ANGPTL8 expression. La presente descripción se relaciona con agentes de ARNi novedosos diseñados para disminuir la expresión de ANGPTL8 en el hígado, donde los agentes de ARNi comprenden restos de administración conjugados con oligonucleótidos opcionalmente a través de un enlazador. Los agentes de ARNi son útiles en el tratamiento de enfermedades que implican la regulación de la expresión de ANGPTL8.