FAB HIGH MANNOSE GLYCOFORMS

The present invention relates to glycosylation patterns at the Fab portion of a monoclonal antibody and methods for the regulation during culture of a microorganism expressing a monoclonal antibody with regulated content of high mannose Fab glycoforms. La presente invención se refiere a patrones de...

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Bibliographische Detailangaben
Hauptverfasser:	JOERIS, Klaus, HOFMANN, Carsten, OEZDEN, Neslihan, LAU, Wilma, SCHMIDT, Britta, STAACK, Roland, RICHTER, Wolfgang
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention relates to glycosylation patterns at the Fab portion of a monoclonal antibody and methods for the regulation during culture of a microorganism expressing a monoclonal antibody with regulated content of high mannose Fab glycoforms. La presente invención se refiere a patrones de glucosilación en la porción Fab de un anticuerpo monoclonal y procedimientos para la regulación durante el cultivo de un microorganismo que expresa un anticuerpo monoclonal con contenido regulado de glucoformas de Fab ricas en manosa.